16.2.2  Macular Hole Repair (Medical Therapy)

Medical therapy to reduce macular edema can facilitate closure of small full thickness macular holes, thus avoiding the need for surgery.[1] This also provides a means of therapy, when vision may still be good or if patients cannot position or cannot function without the vision in the involved eye.

Macular holes are full thickness defects in the retina from the ILM through the photoreceptor layer and are most commonly due to vitreous traction on the macula unless associated with secondary causes, such as trauma, retinal detachment or myopic retinoschisis. Macular holes are usually treated with surgery to relieve traction and to use intraocular tamponade.

Kokame GT, Johnson MW, Lim J, Flynn HJ, de Carlo T, Yannuzzi N, Ryan EH, Omizo JN, Sridhar J, Staropoli P, Goldhagen B, Lian R. Closure of Full-Thickness Macular Holes Associated with Macular Edema with Medical Therapy. Ophthalmologica 2022; 245:179-186.

Pathogenesis of Macular Edema Around Macular Hole

Macular holes are often associated with macular edema around the hole. When there is a break in the internal limiting membrane, vitreous fluid enters and the increasing macular edema contributes to macular hole formation.

Clinical Features for Medical Therapy Closure of Macular Hole

Macular holes considered for medical therapy are small (usually 200μm or less) and do not have significant traction on the fovea visible on optical coherence tomography.

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